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ADNI 2

Download our free app on your phone for easy access to health information and tools Thu, Jun 30, 2011. IDA & Informatics Core. Clinical data from the ADNI 1, ADNI GO and ADNI 2 phases of the project are now available in the the ADNI Repository (IDA) . Once logged in, you may peruse and download assessment, medical history, biospecimen and other data from the DOWNLOAD | Study Data menu. See INSTRUCTIONS for more information ADNI-2 also will continue long-term follow-up of some volunteers previously enrolled in ADNI-1 or ADNI-GO. In addition to other procedures and assessments, all ADNI-2 study participants will undergo brain beta-amyloid imaging. ADNI-2 is funded by the NIA through a $40-million commitment providing $8 million per year for five years Mr 3 Only - Use The Adni Go-Adni 2 Human 7 Protocol. Check The Order To See If This Is A Read. Study Subject Scan: Place a fiducial on the patient's right temple. Position the patient as straight as possible in the 8-Ch Head Coil. There are several pages of paperwork that you must fill out as the scan is running ADNI-2 was funded to enroll additional subjects with AD, LMCI, EMCI, no cognitive impairment, and a new group of subjects manifesting even more subtle degrees of cognitive manifestations either experienced subjectively or observed by others, termed significant memory concerns (SMC). ADNI-2 began in 2011

Alzheimer's disease neuroimaging initiative 2 (ADNI2

  1. The Alzheimer's Disease Neuroimaging Initiative (ADNI) unites researchers with study data as they work to define the progression of Alzheimer's disease (AD). ADNI researchers collect, validate and utilize data, including MRI and PET images, genetics, cognitive tests, CSF and blood biomarkers as predictors of the disease
  2. e the relationships between the clinical, cognitive, imaging, genetic and biochemical biomarker characteristics of the entire spectrum of Alzheimer's disease (AD)
  3. A voxel-based morphometry comparison of the 3.0T ADNI-1 and ADNI-2 volumetric MRI protocols Simon Brunton1,2, Cerisse Gunasinghe1,2, Nigel Jones1, Matthew J Kempton1, Eric Westman1,3 and Andrew Simmons1,2 1King's College London, Institute of Psychiatry, Department of Neuroimaging Sciences, London, UK 2NIHR Specialist Biomedical Research Centre for Mental Health at the South London and.

ADNI 1 ADNI GO & ADNI 2 Clinical Data Available ADN

About Press Copyright Contact us Creators Advertise Developers Terms Privacy Policy & Safety How YouTube works Test new features Press Copyright Contact us Creators. Wrapping Up Enrollment, ADNI 2, PPMI Focus on Earlier Disease. 02 Apr 2013. On 18 March 2013 in San Diego, California—the site of this year's American Academy of Neurology (AAN) annual meeting—the Alzheimer's Disease Neuroimaging Initiative (ADNI) steering committee gathered to exchange the latest developments in this $140 million. When did you download the data? I just downloaded the file and see APGEN1 and APGEN2 for all phases of ADNI (ADNIGO and ADNI-2 are combined in the Phase variable). RIDs in the 2000s are newly enrolled participants in ADNIGO, while RIDs in the 4000s and 5000s are newly enrolled participants in ADNI-2. Danielle - Introduction: The overall goal of the Alzheimer's Disease Neuroimaging Initiative (ADNI) is to validate biomarkers for Alzheimer's disease (AD) clinical trials. ADNI-3, which began on August 1, 2016, is a 5-year renewal of the current ADNI-2 study. Methods: ADNI-3 will follow current and additional subjects with normal cognition, mild cognitive impairment, and AD using innovative technologies. Alzheimer's Disease Neuroimaging Initiative (ADNI) is a multisite study that aims to improve clinical trials for the prevention and treatment of Alzheimer's disease (AD). This cooperative study combines expertise and funding from the private and public sector to study subjects with AD, as well as those who may develop AD and controls with no signs of cognitive impairment

North American ADNI Alzheimer's Associatio

MR ADNI GO/ ADNI 2 Research Protocol OHS

The PDFs below represent a variety of presentations made at WW-ADNI meetings. The material is in its original format and is provided in the spirit of sharing research. The opinions, facts and views expressed here are those of the presenting scientists. In Person Meeting Agenda for Friday, July 11. 1 In the ADNI-2 cohort, 24 EMCI and 50 LMCI subjects converted to AD at the followed-up visits. We used their baseline scans and predicted the MCI conversation to AD. The spectral graph-CNN, trained for CN vs. AD task, corrected predicted the conversion of 18/24 EMCI (75%) and 46/50 (92%) LMCI to AD The final model was validated using an independent dataset from the ADNI-2 cohort. Results: The final model included age, sex, years of education, history of hypertension, apolipoprotein ε4 positivity, and score from a word list recall test. The model predicted that younger age, female sex, higher educational level, absence of hypertension. Objective: Our goal was to evaluate the association of APOE with amyloid deposition, cerebrospinal fluid levels (CSF) of Aβ, tau, and p-tau, brain atrophy, cognition and cognitive complaints in E-MCI patients and cognitively healthy older adults (HC) in the ADNI-2 cohort. Methods: Two-hundred and nine E-MCI and 123 HC participants from the ADNI-2 cohort were included

The Image Data Archive at the Laboratory of Neuro Imaging (IDA) provides a safe repository for medical imaging data. LONI seeks to improve the understanding of the brain in health and disease through the development of algorithms and approaches for the comprehensive and quantitative mapping of its structure and function All participants were recruited within the Alzheimer's Disease Neuroimaging Initiative (ADNI) and enrolled at sites in the United States and Canada across 3 funding cycles (ADNI-1, ADNI-GO, and ADNI-2). 24 They were aged between 55 and 91 years at baseline, English or Spanish speakers, nondepressed, and classified as NC, MCI, or AD dementia. adni-2-bids. - Conversion of the Alzheimer's Disease Neuroimaging Initiative (ADNI) to BIDS. Description adapted from the ADNI website. ADNI is a global research effort that actively supports the investigation and development of treatments that slow or stop the progression of Alzheimer's disease (AD). This multisite, longitudinal study.

Alzheimer's Disease Metabolomics Consortium A partnership

Alzheimer Disease Neuroimaging-2 Study (ADNI-2) Principal Investigator . Dr. Robin Hsiung , MD, FRCP(C) Details. The purpose of this study is to collect brain scans, blood samples, memory test scores, and cerebrospinal fluid from people with Alzheimer Disease (AD), Mild Cognitive Impairment (MCI), or no memory impairment. These data may help. ADNI-2 today i start my alzheimers research study called adni-2 alzheimers disease neuroimaging intiative-2 is an extension of the adni-1 study this study will look at normal controls (thats the category i was going to be in when all this mess ive got myself into started

ADNI-2 + 133 elder controls: 151 MCI. 87 AD. Timeline and Evolution of ADNI and the ADNI-NPC - Two works in progress; 2004 2007 2009 2011 2014 2016 2019 2021; Modeled after. ACDS clinical trial. 5-year consent. No autopsy plan. 59 sites; many w/o. autopsy capability. ADNI-1; ADNI-GO. ADNI-2: ADNI-3 (ADNI-4) Primary goal. Since its launch in 2004, the overarching aim of the Alzheimer's Disease Neuroimaging Initiative (ADNI) has been realized in informing the design of therapeutic trials in AD. ADNI3 continues the previously funded ADNI-1, ADNI-GO, and ADNI-2 studies. San Francisco, California and other locations For ADNI‐2, widespread increases in GM were found relative to ADNI‐1 (cerebellum and pre‐central gyrus), with localised decreases along the midline and temporal lobes. For ADNI‐1, widespread increases in WM were found relative to ADNI‐2 (cerebellum and pre‐central gyrus), together with localised decreases in the temporal gyrus Objectives. The Alzheimer's Disease Neuroimaging Initiative 3.0T MRI image acquisition scheme changed between the original ADNI-1 grant and the two subsequent grants (ADNI-GO and ADNI-2). The aim of the current study was to investigate the compatibility of the 3.0T ADNI-1 and ADNI-2 T1-weighted volumes using voxel-based morphometry (VBM) • Full enrollment of all ADNI 2 Cohorts • Normals: n=184 • Subjective memory concerns: n=101 • Early MCI: n=301 (including ADNI GO) • Late MCI: n=160 • Mild dementia: n=142 • Total enrollment of new participants: n=780 • Rollover participants from ADNI1 and ADNI GO: n=391 • Total for ADNI2: n=117

ADNI Alzheimer's Disease Neuroimaging Initiativ

Bioinformatics/Genomics Pipeline Workflows: Step II Analysis: Data Quality Control and Cleaning using GATK and SAMtools Workflows Overview. This page contains a description of the second stage of the genomics data analysis protocol designed and implemented by Federica Torri, Fabio Macciardi and Main.IvoDinov to process large number of sequence data outputted by the Illumina sequencing pipeline The AUC was 0.85 in the ADNI-2 cohort, indicating the same performance with MRI-based models. Conclusions Our results are twofold: the result has first identified the predictability in MRI markers using ML approaches, and secondly demonstrated the neuropsychological model with demographics could predict Aβ positivity, suggesting a more cost. Currently in ADNI 2, the study is now focusing on the rate of change of cognition, function, brain structure and biomarkers of 850 volunteers. The ADNI participants are grouped in four clusters: 150 elderly controls, 450 individuals with mild cognitive impairment, 150 individuals with mild to moderate AD and 100 individuals with significant.

Program. Each component of the WUSTL ENDURE program is designed to provide trainees a solid foundation for future success. This begins with hypothesis-driven research in a world-class Washington University lab where students gain research skills and a taste of life as a graduate student This identified 4 and 6 additional samples, respectively, that were excluded from the final data matrices for ADNI 1 and ADNI 2/GO. Finally, all metabolites were log2 transformed One could then include in ADNI 2 a test of whether the standardized approach we took holds up as the most robust and well-behaved measure in a subsequent study. Obviously, if we all come to believe that the FDG-PET data is clear enough to support standardization around a single common approach, all the better The Alzheimer's Disease Neuroimaging Initiative (ADNI) is a longitudinal multicenter study designed to develop clinical, imaging, genetic, and biochemical biomarkers for the early detection and tracking of Alzheimer's disease (AD). Since its launch in 2004, the landmark public-private partnership has made major contributions to AD research, enabling the sharing o Alzheimer's Disease Neuroimaging Initiative (ADNI-2) (Protocol #10-27-H-09) Would you like to participate in a study to look at the usefulness of brain scans, markers in your blood and spinal fluid, together with measurements of memory, thinking and daily functioning, in the identification of Alzheimer's disease at an early stage

Initiative - Phase 2, or ADNI 2. This international study began seven years ago and was designed to find the best ways to measure the effects of Alzheimer's treatments. The goal has since expanded to use biomark-ers, or proteins found in blood, to identify Alzheimer's before the onset of dementia. After researching Alzheimer' Normative models were computed separately for ADNI-1 and ADNI-2 given different scanner acquisition protocols between the two datasets. Next, we used the beta-term maps for age and gender, as well as the maps of the residuals from these normative models, to calculate a vertex-wise w-score for cortical thickness in each patient (a w-score is a z. Additional 550 enrolled participants with ADNI GO + ADNI 2, focusing on earliest phases of AD process. Clark et al, JAMA, 2011 . Shaw et al, Ann Neurol 2009 . CSF biochemical biomarkers might discriminate who would convert to AD. Specific PET ligands might detect amyloi the ADNI-2 with complete available baseline data re-garding cognitive assessment, CSF markers and PET Aβ quantitation. Our cross-sectional sample was made up of 677 subjects (157 control subjects, 95 with SMC, 301 with MCI among whom 153 had early MCI and 148 had late MCI, and 124 with AD at the time of the florbetapi

IMPACT OF PARALLEL IMAGING ON VOLUMETRIC BRAIN MRI MEASUREMENTS IN ADNI-GO AND ADNI-2 1 1 1 1 1 1 1 1 S. Gouttard , J. Schaerer , H.J. Yu , A. Istace , F. Roche , C. Pachai , L. Bracoud and the Alzheimer's Disease Neuroimaging Initiative BioClinica, Lyon, France & Newtown, PA, USA - email: Sylvain.Gouttard@bioclinica.com INTRODUCTION Statistical analysis ROC analysis led to similar areas under. ADNI-2 did not show evidence of inflation (Additional file 2: Figure S2). We compared the GWAS ranked and NetWAS reprioritized genes to genes with a documented association with Alzheimer's disease in the OMIM database using the AUC (Fig. 2 )

UCSF Mild Cognitive Impairment Trial → Alzheimer's Disease

A voxel-based morphometry comparison of the 3

This study continues the previously funding ADNA-1, ADNI-GO, and ADNI-2 studies that have been combined public/private collaborations between academia and industry to determine the relationships between the clinical, cognitive, imaging, genetic and biochemical biomarker characteristics of the entire spectrum of Alzheimer's disease (AD) The prediction ability of candidate markers for cerebral Aβ status was examined by analyzing 724 participants from the ADNI-2 cohort. Demographic variables, structural MRI markers, and neuropsychological test scores were used as input in several ML algorithms to predict cerebral Aβ positivity Recent work by the Alzheimer's Disease Neuroimaging Initiative (ADNI) 2 PET Core have examined the combined utility of FDG-PET and amyloid PET at tracking progression of the disease. For example, they demonstrate that amyloid PET (using florbetapir uptake) is negatively associated with temporoparietal metabolism 21 question alzheimers questionnaire (13) a4 study (4) AD8 test (3) adni-2 (31) affordable care act (12) alzheimer worms (3) alzheimers (185) alzheimers 10 signs (11) alzheimers action plan (1) alzheimers blood test (3) alzheimers disease (164) alzheimers disease center (11) alzheimers disease neuroimaging intiative (19) alzheimers graph (2.

David T. Jones, M.D., is a neurologist with specialty interest in cognitive and behavioral neurology, network-based neurodegeneration, and the application of multimodal neuroimaging with an emphasis on MRI and PET. He is the co-director of the Normal Pressure Hydrocephalous Clinic and a passionate advocate for these patients This blog will run for the length of my participation as a volunteer for the multi-national research project named ADNI-2. If all goes as planned, that will last for 5 years--until 2017. This year (2012) there will be more postings than subsequent years because I am just getting enrolled projects where they had received an ADNI unaccelerated MPRAGE (ADNI 2 sequence), while new subjects were generally scanned with an ADNI 2x accelerated (GRAPPA) MPRAGE (note this is the same sequence that is used in ADNI 2 GO and the Dominantly Inherited Alzheimer's disease Network (DIAN)) ADNI-1,ADNI-GO,ADNI-2,andADNI-3phases.Weselected those individuals who had at least 1 year clinical follow-up available and met the inclusion criteria that were used in the recentEMERGEandENGAGEtrials17:(1)aclinicaldiagnosis of mild cognitive impairment (MCI) or dementia; (2) elevated amyloidasmeasuredbyPETimaging(specific procedures an ADNI 2 /ADNI GO Athersys B01 Bayer Asteroid BIOGEN IDEC Biogen- Ascend CSOM230C - Acromegaly DeNovo Knee EISAI Focus FH/MIPO Games- RP Gaucher Histogenic Knee (MR3) INCB INI (Insulin) ISIS Kinespring Meeker Achilles - new 9/2020 Norvartis Cain 457F2302 Novartis CCNP520A2202J (5175) (Subject) Novartis CLCI699 Pfizer A3921119 PPMI Roche Scarlet.

ADNI-2 started in 2011 and used a modified set of protocols that were designed to support systems that have since been upgraded and to solve problems of variability and improve reliability and efficiency from the original ADNI-1 sequences whilst maintaining the essential requirement of compatibility ADNI 2 (Alzheimer's Disease Neuroimaging Initiative 2) ADNI 2的建立基于ADNI一期阶段确定阿尔茨海默病的早期迹象的成功。研究人员怀疑在出现AD症状之前,大脑已经有了可以识别到的变化,因此ADNI 2阶段的研究增加了大量认知障碍早期的参与者

The Alzheimer's Disease Cooperative Study (ADCS) was formed in 1991 as a cooperative agreement between the National Institute on Aging (NIA) and the University of California, San Diego.The ADCS is a major initiative for Alzheimer's disease (AD) clinical studies in the Federal Government, addressing treatments for both cognitive and behavioral symptoms ADNI-2-BIDS Field Mapping Support. Identify field maps from relevant sessions. Identify phasediff and magnitude series. Convert 3 of 3. Total price: $24.98. Add both to Cart Add both to List. These items are shipped from and sold by different sellers. Show details. Buy the selected items together. This item: Kyocera HTNBK scissors sharpener $14.99. In Stock. Sold by Cool JP Trading LLC and ships from Amazon Fulfillment. FREE Shipping on orders over $25.00 zheimer's Disease Neuroimaging Initiative (ADNI)-1, ADNI-2, and ADNI-GO (Grand Opportunities) studies (Appendix E1 [online]). Data regarding the patient's final diagnoses were downloaded from the ADNI web portal (adni.loni.ucla.edu) (11). Detailed 18F-FDG PET imaging protocols can be foun

throwback marissa + adni(2) - YouTub

The predictability in candidate markers for cerebral Aβ status was examined by analyzing 724 participants from the ADNI-2 cohort. Demographic variables, structural MRI markers, and neuropsychological test scores were used as input in several ML algorithms to predict cerebral Aβ positivity ADNI 2 is the continuation of ADNI 1 and ADNI GO and will enroll 150 healthy controls and 250 MCI (100 early and 150 late) who will all undergo F18 amyloid PET with florpiramine and MR imaging on 3T magnets. If it is assumed that the population recruited for ADNI 2 is similar to the population recruited for ADNI1 it can be expected that about.

MRI images of 91 Mild Cognitive Impairment (MCI) and 79 Normal Controls were acquired from ADNI-2 data set along with their genetic information and used this genetic information to find the prevalence between MCI and age, gender and ApoE. They used Data Processing and Analysis of Brain Imaging (DPABI) for pre-processing ADNI 2 Private Partner Scientific Board: Adam Schwartz, MD, Eli Lilly (Chair). Data and Publication Committee: Robert C. Green, MD, MPH, Brigham and Women's Hospital/Harvard Medical School (Chair). Resource Allocation Review Committee: Tom Montine, MD, PhD, University of Washington (Chair) Nationally, the study is short by thousands of volunteers, and the largest and most comprehensive study, ADNI-2, a $140m project, was roughly 250 patients short of its enrolment goal in May 2012. Improving awareness: key to improving patient recruitmen The set of D2 entries contains all currently available longitudinal data for prospective ADNI-3 subjects that are rollovers from earlier ADNI studies. Such subjects are active (PTSTATUS=='1'), with ADNI-2 visits (Phase=='ADNI2'), and screening was performed (RGSTATUS=='1'). These subjects were identified as follows UAB has participated in each phase of this study, including ADNI-1, ADNI-GO, ADNI-2, and now ADNI-3. Dr. Geldmacher is the UAB site PI. Alzheimer's Disease Genetics Consortium (ADGC). The ADGC is an NIH-funded collaboration between Alzheimer's Disease Centers across the U.S. to identify genetic variants that contribute to AD risk

Wrapping Up Enrollment, ADNI 2, PPMI Focus on Earlier

ADNI 2 ApoE Allele info - groups

In addition, in ADNI-2, MCI is divided further into 'early MCI' (EMCI) and 'late MCI' (LMCI), and in this analysis, the MCI subtypes were combined. Thirty-two individuals that had only a screening visit/diagnosis (preceding the baseline visit/diagnosis) were excluded from the analysis. Out of the 698 individuals that developed dementia. The Wake Forest Alzheimer's Disease Research Center is enrolling clinical research participants in the Healthy Brain Study. The purpose of this study is to follow participants over time, collecting cognitive data, brain images and biological samples at regular intervals to better understand what constitutes brain aging and which risk factors lead to Alzheimer's disease We intend to study dysfunctional large scale brain networks (LSBNs) in DLB by comparing rs-fMRI imaging data in this population with cognitively normal (CN) and mild Alzheimer's disease (AD) subjects from the Alzheimer's Disease Neuroimaging Initiative (ADNI)-2/3 database As described in the Methods section, the image acquisition protocols of ADNI-2 were designed to ensure the consistency of PET data within and between sites, particularly in terms of spatial resolution (via post-smoothing) and signal-to-noise ratio (via injected doses, injection-to-acquisition delay, and scan duration) Therefore, the ADNI-2 ASL acquisition protocol requires a set of 52 pairs of repeated tagged and untagged image frames which are then averaged to increase the SNR. Many variants of ASL have been developed over the years, such as continuous, pulsed, and velocity selective labeling

has been followed by ADNI-GO and ADNI-2. To date, these three protocols have recruited over 1500 adults, ages 55-90, to participate in the research, consisting of cognitively normal older individuals, people with early or late MCI, and people with early AD. The follow up duration of each group is specified in the proto-col High quality example sentences with this project was made possible in context from reliable sources - Ludwig is the linguistic search engine that helps you to write better in Englis

The Alzheimer's Disease Neuroimaging Initiative 3

Individuals with amnestic MCI or early Alzheimer's dementia and age-matched cognitively normal subjects were recruited to ADNI-1, ADNI-2, and ADNI-GO from over 50 sites across the United States and Canada. All sites had approval by their respective institutional review boards, and written informed consent was obtained from all participants More recent subtypes (under investigation in the Alzheimer's Disease Neuroimaging Initiative (ADNI) Go and ADNI 2 trials) include early and late MCI. Early MCI represents subtle memory impairment that is intermediate between normal subjects and late MCI, as determined by say, education-adjusted scores on the Wechsler Memory Scale. The Alzheimer's Disease Research Center (ADRC) at Wake Forest School of Medicine brings together the latest technologies in neuroscience, neuropsychology, brain imaging and new treatments—all helping to find new ways to slow brain aging. The ADRC studies the role of metabolic and vascular risk factors in promoting the transition from normal.

Alzheimer's Disease Neuroimaging Initiative - Wikipedi

ADNI-GO and ADNI-2 studies were conducted according to Good Clinical Practice guidelines, US 21CFR Part 50 - Protection of Human Subjects, and Part 56 - Institutional Review Boards (IRBs)/Research Ethics Boards (REBs), and pursuant to state and federal HIPAA regulations. Study protocols were approved by each site'sIRB/ REB (Additonal file 1) Subjective cognitive decline (SCD) is regarded as the first clinical manifestation in the Alzheimer's disease (AD) continuum. Investigating populations with SCD is important for understanding the early pathological mechanisms of AD and identifying SCD-related biomarkers, which are critical for the early detection of AD. With the advent of advanced neuroimaging techniques, such as positron. Introduction. Although Alzheimer disease (AD) remains a diagnosis based on clinical grounds (1,2), advancements in diagnostic technology such as PET with fluorine 18 (18 F) fluorodeoxyglucose (FDG) allow earlier diagnosis and treatments, when they may be most effective ().There is a continuous spectrum from normal cognition to AD, including mild cognitive impairment (MCI) as a prodromal stage. followed by ADNI-GO and ADNI-2. To date these three protocols have recruited over 1500 adults, ages 55 to 90, to participate in the research, consisting of cognitively normal older individuals, people with early or late MCI, and people with early AD. The follo Conventional diagnostic criteria, as operationalized by ADNI []Participants were diagnosed with MCI by ADNI if the following criteria were met: (1) there was a subjective memory concern reported by the participant or an informant; (2) the participant's total score on the MMSE was between 24-30 (inclusive); (3) the participant's total score on the Global CDR was 0.5; (4) the participant.

Alzheimer's Disease Neuroimaging Initiative 3 (ADNI3

Schneider and colleagues 1 examined this issue in the observational Alzheimer Neuroimaging Initiative (ADNI) 2 database. Among the 402 participants with MCI due to AD, 44.0% were receiving ChEIs and 11.4% were receiving memantine at baseline; among the 188 participants with dementia due to AD, 84.6% were receiving ChEIs and 45.7% were receiving. The ADNI is the result of effort of many coinvestigators from a broad range of academic institutions and private corporations, and subjects have been recruited from >50 sites across the United States and Canada. The initial goal of ADNI was to recruit 800 subjects, but ADNI has been followed by ADNI-Grand Opportunity and ADNI-2 about alzheimers disease 2 adni 2.1 epidemiology 2.2 major achievements of adni 2.3 quality control 2.4 loni data archive 2.5 adni- mri core 3. purpose of mri 3.1mri 3.2 material and methods in mri of adni 4. multi atlas selection 4.1 registration and segmentation 4.2 automated temporal lobe This cross-sectional study of 598 amyloid-positive participants in the Alzheimer's Disease Neuroimaging Initiative cohort examined whether levels of soluble Aβ42 are higher in amyloid-positive normal cognition (NC) individuals compared to mild cognitive impairment (MCI) and Alzheimer's disease (AD) and whether this relationship applies to neuropsychological assessments and hippocampal volume.

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